1、 Separation and purification of active ingredients in traditional Chinese medicine

Natural medicine extraction: to separate active ingredients such as alkaloids, flavonoids, saponins, etc. from traditional Chinese medicine, and meantime to achieve high-purity extraction through adsorption retention time differences.

Impurity removal: Remove interfering substances such as pigments and tannins from the extraction solution to improve the purity of the drug.

2、 Chemical synthesis drug refining

Intermediate purification: Separate and purify intermediates during the synthesis process to remove by-products and residual catalysts.

Chiral Separation: Utilizing the differential adsorption of silanol groups on the surface of silica gel to separate enantiomers (such as chiral drugs).

3、 Biopharmaceutical field

Peptide and protein purification: Large pore silica gel (such as C-type, pore size>10nm) is used to purify peptides, proteins, and antibiotics with molecular weights ranging from 500 to 40000.

Separation of nucleic acid substances: Purification of biological macromolecules such as oligonucleotides and nucleotides.

4、 API Preparation

Final product refinement: Remove trace impurities through gradient elution technology to ensure that the raw material meets pharmacopoeia standards.

Solvent residue control: adsorb residual organic solvents (such as methanol, ethyl acetate).

5、 Medicinal excipients and carriers

Catalyst carrier: an inert carrier used for solid-phase synthesis or catalytic reactions.

Drug release materials: Use their porous structure to control the drug release rate.

Key parameters for technical selection:

Note: it is necessary to optimize the pore diameter, particle size, and elution system of silica gel based on the polarity, molecular weight, and separation scale of the target molecule.